Article

Engineering self-deliverable ribonucleoproteins for genome editing in the brain

2023-11-15

Abstract excerpt

The delivery of CRISPR ribonucleoproteins (RNPs) for genome editing in vitro and in vivo has important advantages over other delivery methods, including reduced off-target and immunogenic effects 1 . However, effective delivery of RNPs remains challenging in certain cell types due to low efficiency and cell toxicity. To address these issues, we engineered self-deliverable RNPs that can promote efficient cellula...

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Literature Corpus work: a6cf1bdd-7537-55c4-9cb4-6f17c50bc461
DOI: 10.1101/2023.11.15.567251

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