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Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes

25 Nov 2019

Abstract excerpt

Dietary restriction (DR) is a well-established intervention to extend lifespan across taxa. Recent studies suggest that DR-driven lifespan extension can be cost-free, calling into question a central tenant of the evolutionary theory of aging. Nevertheless, boosting parental longevity can reduce offspring fitness. Such intergenerational trade-offs are often ignored but can account for the "missing costs" of...

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PMID: 31761926
DOI: 10.1093/gerona/glz276

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