Article
HIV drug resistance during antiretroviral therapy scale-up in Uganda, 2012-19: a population-based, longitudinal study.
The Lancet. Microbe - 1 Dec 2025
Martin Michael A, Reynolds Steven James, Foley Brian T, Nalugoda Fred, Quinn Thomas C, Kemp Steven A, Nakalanzi Margaret, Kankaka Edward Nelson, Kigozi Godfrey, Ssekubugu Robert, Gupta Ravindra K, Abeler-Dörner Lucie, Kagaayi Joseph, Ratmann Oliver, Fraser Christophe, Galiwango Ronald Moses, Bonsall David, Grabowski M Kate
Abstract excerpt
BACKGROUND: With scale-up of antiretroviral therapy (ART) in sub-Saharan Africa, increasing pretreatment HIV drug resistance has been reported; however, the broader effect of ART expansion on population-level resistance patterns remains insufficiently quantified. We aimed to estimate the longitudinal prevalence of drug resistance and resistance-conferring mutations. METHODS: This study used data collected as part...
Topics
- Humans
- Adult
- Uganda
- HIV Infections
- Drug Resistance, Viral
- Longitudinal Studies
- Male
- Female
- Middle Aged
- Young Adult