Article

A Refined, Controlled 16S RRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis

2021-10-21

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold>Advances inboth laboratory and computational components of high-throughput 16S amplicon sequencing (16S HTS) have markedly increased its sensitivity and specificity. Additionally, these refinements have better delineated the limits of sensitivity, and contributions of contamination to these limits, for 16S HTS that are particularly relevant for samples with low b...

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Literature Corpus work: a65b4622-b17c-54d0-88e9-9ae93f9a2766
DOI: 10.21203/rs.3.rs-966673/v1

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