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Uncovering Hidden Pathogens in Culture Negative Cases: Enhancing Diagnostic Utility in Post-Neurosurgical Meningitis/Ventriculitis Using 16S Metagenomics

2025-12-06

Abstract excerpt

Post-neurosurgical Meningitis/Ventriculitis remains a major clinical challenge, particularly in cases where conventional microbiological cultures yield negative results. Delayed or improper diagnosis can lead to sepsis or even death in patients. 16S metagenomics next-generation sequencing (mNGS) techniques have higher sensitivity and specificity than gold-standard techniques. This prospective study aimed to evalua...

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Literature Corpus work
52357dd3-129e-53ab-b232-6116e58409d5
DOI
10.64898/2025.12.05.25341694
Open publication

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