Article

Enteric neurons modulate colorectal cancer cell cycle through a PCSK1 - Methionine-Enkephalin Axis

2026-05-06

Abstract excerpt

<h4>Background and Aims</h4> The tumor microenvironment in colorectal cancer (CRC) is richly innervated, yet the contribution of the enteric nervous system (ENS) to CRC biology remains poorly defined. ENS neurons express proenkephalin (PENK), which can be processed by proprotein convertase 1/3 (PCSK1) to generate Methionine-enkephalin (M-ENK), a bioactive peptide with growth-regulatory potential. We hypothesized...

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Literature Corpus work: 94a3876b-cb4f-539f-8086-71145147d148
DOI: 10.64898/2026.05.03.722515

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