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Inflammatory microenvironment impairs the therapeutic effect of daratumumab-lenalidomide in multiple myeloma

2025-04-28

Abstract excerpt

Daratumumab and lenalidomide (DR) combination therapy improves multiple myeloma outcomes, yet some patients respond poorly. We examined 56 DR pre-treatment samples from the IFM2017 Phase 3 trial using multiomics approaches to identify determinants of response. Analysis of bone marrow environment revealed critical synergy between inflamed myeloma cells and inflammatory immune microenvironment contributing to treatm...

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Literature Corpus work
a61a48ce-9666-56c1-8788-085e7c76debb
DOI
10.1101/2025.04.23.25325569
Open publication

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Inflammatory microenvironment impairs the therapeutic effect of daratumumab-lenalidomide in multiple myelomaDOI 10.1101/2025.04.23.25325569
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