Article

The Oncogenic Role of Human Microcephalin Gene Revealed by Pan-Cancer Analysis

2022-11-20

Abstract excerpt

The human gene microcephalin ( MCPH1 ) plays a key role in DNA damage-induced cellular responses and chromosome condensation. Recent clinical studies proposed MCPH1 as a tumor suppressor gene in lung cancer, pancreatic cancer, and breast cancer, yet its roles remain poorly understood in other types of tumors. Pan-cancer analyses of MCPH1 are urgently required to help us understand the potential molecular functions...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5998f3b-c7c4-5508-b381-f52bc452fb42
DOI: 10.1101/2022.11.18.22282275

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Oncogenic Role of Human Microcephalin Gene Revealed by Pan-Cancer AnalysisDOI 10.1101/2022.11.18.22282275Read

Multifaceted Microcephaly-Related Gene MCPH1.Semantic proximity Read

MCPH1 protein expression and polymorphisms are associated with risk of breast cancer.Semantic proximity Read

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.Semantic proximity Read

Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma.Semantic proximity Read

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.Semantic proximity Read

Pan-cancer analysis of BLM as a prognostic and immunological marker in human tumorsSemantic proximity Read

A pan-cancer analysis of RNASEH1, a potential regulator of the tumor microenvironment.Semantic proximity Read

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.Semantic proximity Read

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.Semantic proximity Read

A pan-cancer analysis reveals CHD1L as a prognostic and immunological biomarker in several human cancersSemantic proximity Read

The potential role of nucleophosmin (NPM1) in the development of cancer.Semantic proximity Read

Molecular characteristics and oncogenic role of CHD family genes: a pan-cancer analysis based on bioinformatic and biological analysis.Semantic proximity Read