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Article

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.

EMBO reports - 1 Sept 2008

Yang Shan-Zhong, Lin Fang-Tsyr, Lin Weei-Chin

Abstract excerpt

Microcephalin (MCPH1) has a crucial role in the DNA damage response by promoting the expression of Checkpoint kinase 1 (CHK1) and Breast cancer susceptibility gene 1 (BRCA1); however, the mechanism of this regulation remains unclear. Here, we show that MCPH1 regulates CHK1 and BRCA1 through the interaction with E2F1 on the promoters of both genes. MCPH1 also regulates other E2F target genes involved in DNA repair...

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Source

Open in PubMed Open full text

Identifiers

PMID: 18660752
DOI: 10.1038/embor.2008.128
PMCID: PMC2529348

Genes

MCPH1
BRCA1
DDB2
RAD51
TOPBP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.PMID 18660752Read ↗

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