Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MCPH1 protein expression and polymorphisms are associated with risk of breast cancer.

Gene - 1 Apr 2013

Jo Yong Hwa, Kim Hye Ok, Lee Juhie, Lee Sang Sook, Cho Chang Hoon, Kang In Sug, Choe Won Jae, Baik Hyung Hwan, Yoon Kyung-Sik

Abstract excerpt

Microcephalin 1 (MCPH1) has a crucial role in the DNA damage response by promoting the expression of checkpoint kinase 1 (CHK1) and breast cancer susceptibility gene 1 (BRCA1). MCPH1 containing BRCT domain has been suggested as a tumor suppressor in breast and ovarian cancers. We analyzed the effect of both protein expression and MCPH1 polymorphisms in breast cancer patients. Low nuclear expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve Tissue Proteins
Share to Aged
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Cytoskeletal Proteins

Share to Polymorphism, Single Nucleotide

Share to Receptors, Estrogen

Share to Republic of Korea

Source

Identifiers

PMID: 23296058
DOI: 10.1016/j.gene.2012.12.088

Genes

MCPH1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MCPH1 protein expression and polymorphisms are associated with risk of breast cancer.PMID 23296058Read ↗

The Oncogenic Role of Human Microcephalin Gene Revealed by Pan-Cancer AnalysisSemantic proximity Read ↗

MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis.Semantic proximity Read ↗

Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma.Semantic proximity Read ↗

Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility.Semantic proximity Read ↗

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.Semantic proximity Read ↗

Multifaceted Microcephaly-Related Gene MCPH1.Semantic proximity Read ↗

Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases.Semantic proximity Read ↗

DNA Repair Proteins MCPh1 and BRD4 Expression and Association with Immune Checkpoint Markers in Endometrial CarcinomaSemantic proximity Read ↗

Frequent Alterations of MCPH1 and ATM are Associated with Primary Breast Carcinoma: Clinical and Prognostic ImplicationsSemantic proximity Read ↗

Prenatal Identification of a Novel Mutation in the MCPH1 Gene Associated with Autosomal Recessive Primary Microcephaly (MCPH) using Next Generation Sequencing (NGS)Semantic proximity Read ↗

The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo.Semantic proximity Read ↗

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.