Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Villard Elise F, EI Khoury Petra, Frisdal Eric, Bruckert Eric, Clement Karine, Bonnefont-Rousselot Dominique, Bittar Randa, Le Goff Wilfried, Guerin Maryse

Abstract excerpt

OBJECTIVE: We investigated the impact of several genetic variants located in genes encoding for proteins involved in biogenesis, maturation, and intravascular remodeling of high density lipoprotein (HDL) particles on plasma efflux capacity. APPROACH AND RESULTS: The capacity of whole-plasma to mediate cholesterol efflux from cholesterol-loaded human THP-1 macrophages was measured in 846 individuals (450 men and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-I
Share to Apolipoprotein A-II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter 1

Share to Cholesterol Ester Transfer Proteins

Share to Cholesterol, HDL

Share to Cholesterol, LDL

Share to Lipase

Share to Lipid Metabolism

Source

Identifiers

PMID: 23372063
DOI: 10.1161/ATVBAHA.112.300979

Genes

ABCA1
APOA1
LIPC
CETP

Variants

rs1799837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determination of plasma cholesterol efflux capacity is gender-specific and independent of HDL-cholesterol levels.PMID 23372063Read ↗

Genetics of cholesterol efflux.Semantic proximity Read ↗

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.Semantic proximity Read ↗

Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects.Semantic proximity Read ↗

Variants at the APOE/C1/C2/C4 Locus Modulate Cholesterol Efflux Capacity Independently of High‐Density Lipoprotein CholesterolSemantic proximity Read ↗

Novel association between CDKAL1 and cholesterol efflux capacity: Replication after GWAS-based discovery.Semantic proximity Read ↗

Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux CapacitySemantic proximity Read ↗

Effect of Anacetrapib on Cholesterol Efflux Capacity: A Substudy of the DEFINE Trial.Semantic proximity Read ↗

Identification of a novel human cellular HDL biosynthesis defect.Semantic proximity Read ↗

Increased prevalence of clinical and subclinical atherosclerosis in patients with damaging mutations in ABCA1 or APOA1.Semantic proximity Read ↗

Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants.Semantic proximity Read ↗

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1.Semantic proximity Read ↗

DNA Methylation and High-Density Lipoprotein Functionality-Brief Report: The REGICOR Study (Registre Gironi del Cor).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.