Article

Suppression of aminoglycoside-induced premature termination codon readthrough by the TRP channel inhibitor AC1903

2021-04-09

Abstract excerpt

Nonsense mutations, which occur in ~11% of patients with genetic disorders, introduce premature termination codons (PTCs) that lead to truncated proteins and promote nonsense-mediated mRNA decay. Aminoglycosides such as gentamicin and G418 permit PTC readthrough and so may address this problem. However, their effects are variable between patients, making clinical use of aminoglycosides challenging. In this study,...

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Literature Corpus work: a572e4e0-7aac-5327-a798-e59a67215524
DOI: 10.1101/2021.04.07.438788

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