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Article

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides.

Nucleic acids research - 19 Aug 2016

Baradaran-Heravi Alireza, Balgi Aruna D, Zimmerman Carla, Choi Kunho, Shidmoossavee Fahimeh S, Tan Jason S, Bergeaud Célia, Krause Alexandra, Flibotte Stéphane, Shimizu Yoko, Anderson Hilary J, Mouly Vincent, Jan Eric, Pfeifer Tom, Jaquith James B, Roberge Michel

Abstract excerpt

Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low efficiency. Using a high-throughput screen, we identified compounds that potentiate readthrough by aminoglycosides at multiple nonsense alleles in yeast. Chemical optimization...

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Identifiers

PMID: 27407112
DOI: 10.1093/nar/gkw638
PMCID: PMC5001621

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DMD
SMARCAL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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