Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells.

Abstract excerpt

Nonsense mutations, generating premature termination codons (PTCs), account for 10% to 30% of the mutations in tumor suppressor genes. Nonsense translational suppression, induced by small molecules including gentamicin and G418, has been suggested as a potential therapy to counteract the deleterious effects of nonsense mutations in several genetic diseases and cancers. We describe here that NB124, a synthetic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aminoglycosides
• Share to bcl-2-Associated X Protein