Article

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach

2011-01-01

Abstract excerpt

Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain of a transmembrane Notch receptor in an adjacent cell. Ligand binding triggers two sequential proteolytic cleavages that shed a Notch intracellular domain (NICD). T...

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Identifiers and source

Literature Corpus work: a532a683-569a-5421-a16c-2495f43bc96e
DOI: 10.17863/cam.16524

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