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Article

Metabolomic networks connect host-microbiome processes to human Clostridioides difficile infections

11 Aug 2019

Abstract excerpt

Clostridioides difficile infection (CDI) accounts for a substantial proportion of deaths attributable to antibiotic-resistant bacteria in the United States. Although C. difficile can be an asymptomatic colonizer, its pathogenic potential is most commonly manifested in patients with antibiotic-modified intestinal microbiomes. In a cohort of 186 hospitalized patients, we showed that host and microbe-associated...

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PMID: 31403473
DOI: 10.1172/jci126905

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