Article

In Silico Directed Evolution of Humanized Peptide Transporters via Attention-Guided Epistatic Rescue

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>The human intestinal peptide transporter 1 (SLC15A1, PepT1) is a critical determinant of oral drug bioavailability, yet its thermodynamic characterization and structural tractability remain challenging. While bacterial orthologues like the Escherichia coli DtpA transporter offer highly stable structural surrogates, significant cross-species variations in the binding microenvironment lim...

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Literature Corpus work: a52aa56f-4399-5c5d-91f7-a855f70180cc
DOI: 10.21203/rs.3.rs-9198655/v1

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