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Structural and mechanistic insights into <i>Plasmodium</i> eIF2alpha dephosphorylation by UIS2 during the erythrocytic stage

2024-06-27

Abstract excerpt

UIS2 is a promising therapeutic target for malaria due to its essential role in the transmission and infectivity of Plasmodium to the host hepatocytes. In Plasmodium , UIS2 acts as a phosphatase toward phosphorylated eIF2alpha at Ser59, regulating translation initiation. However, its role during the erythrocytic stage, which causes clinical symptoms, remains unclear, and its protein structure for elucidating the...

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Literature Corpus work
a5190d94-d519-5ffe-a59d-eaee6ec9021c
DOI
10.1101/2024.06.25.600622
Open publication

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Structural and mechanistic insights into <i>Plasmodium</i> eIF2alpha dephosphorylation by UIS2 during the erythrocytic stageDOI 10.1101/2024.06.25.600622
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