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Article

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2012

Zhang Min, Mishra Satish, Sakthivel Ramanavelan, Rojas Margarito, Ranjan Ravikant, Sullivan William J, Fontoura Beatriz M A, Ménard Robert, Dever Thomas E, Nussenzweig Victor

Abstract excerpt

In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium, the protozoan that causes malaria, expresses three eIF2α kinases: IK1, IK2, and PK4. Like GCN2, IK1 regulates stress response to amino acid starvation. IK2 inhibits...

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Identifiers

PMID: 22355110
DOI: 10.1073/pnas.1121567109
PMCID: PMC3309761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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