Article

Interactions among mTORC, AMPK, and SIRT: A Computational Model for Cell Energy Balance and Metabolism

2020-10-08

Abstract excerpt

Key proteins such as mTORC, AMPK, and sirtuins are known to play an essential role in the management of metabolic stress and ageing mechanisms. An impairment in these mechanisms is commonly associated with cellular ageing and degenerative diseases. To understand the complex interactions of ageing□related signalling pathways and environmental signals, and the impacts on lifespan and health-span, we developed a comp...

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Literature Corpus work: 6dfab138-375a-5068-a59e-585bfbcc00d9
DOI: 10.1101/2020.10.07.330308

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