Article

Lipid Biosynthesis Perturbation Impairs Endoplasmic Reticulum-Associated Degradation

2022-12-10

Abstract excerpt

<h4>ABSTRACT</h4> The relationship between lipid homeostasis and protein homeostasis (proteostasis) is complex and remains incompletely understood. We conducted a screen for genes required for efficient degradation of Deg1 -Sec62, a model aberrant translocon-associated substrate of the endoplasmic reticulum (ER) ubiquitin ligase Hrd1, in Saccharomyces cerevisiae . This screen revealed that INO4 is required for...

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Literature Corpus work: a4843e08-74d5-52c6-b4bc-2bdd0fd382a6
DOI: 10.1101/2022.12.09.519544

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