Lipid biosynthesis perturbation impairs endoplasmic reticulum-associated degradation.

doi:10.1016/j.jbc.2023.104939

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Article

Lipid biosynthesis perturbation impairs endoplasmic reticulum-associated degradation.

The Journal of biological chemistry - 1 Aug 2023

Turk Samantha M, Indovina Christopher J, Miller Jacob M, Overton Danielle L, Runnebohm Avery M, Orchard Cade J, Tragesser-Tiña Mary E, Gosser Samantha K, Doss Ellen M, Richards Kyle A, Irelan Courtney Broshar, Daraghmi Mahmoud M, Bailey Connor G, Niekamp Julia M, Claypool Kieran P, Engle Sarah M, Buchanan Bryce W, Woodruff Kelsey A, Olesen James B, Smaldino Philip J, Rubenstein Eric M

Abstract excerpt

The relationship between lipid homeostasis and protein homeostasis (proteostasis) is complex and remains incompletely understood. We conducted a screen for genes required for efficient degradation of Deg1-Sec62, a model aberrant translocon-associated substrate of the endoplasmic reticulum (ER) ubiquitin ligase Hrd1, in Saccharomyces cerevisiae. This screen revealed that INO4 is required for efficient Deg1-Sec62...

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Identifiers

PMID: 37331602
DOI: 10.1016/j.jbc.2023.104939
PMCID: PMC10372827

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