Article

Scaling of cellular proteome with ploidy

2021-05-07

Abstract excerpt

Ploidy changes are frequent in nature and contribute to evolution, functional specialization and tumorigenesis (1,2). Analysis of model organisms of different ploidies revealed that increased ploidy leads to an increase in cell and nuclear volume, reduced proliferation (2-4), metabolic changes (5), lower fitness (6,7), and increased genomic instability (8,9), but the underlying mechanisms remain poorly understood....

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Literature Corpus work: a46c36ca-940b-56b7-a0dd-e3879d00bf3a
DOI: 10.1101/2021.05.06.442919

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