Article

Defect of Villous Cytotrophoblast Differentiation into Syncytiotrophoblast in Down's Syndrome

2000-10-01

Abstract excerpt

The syncytiotrophoblast (ST) is one of the major components of the human placenta, as it is involved in feto-maternal exchanges and the secretion of pregnancy-specific hormones. The aim of this study was to elucidate the formation and function of the ST in trisomy 21 (Down's syndrome). We first used the in vitro model of cytotrophoblast differentiation into ST. Cytotrophoblasts were isolated from 15 trisomy 21-aff...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a429b4db-4dc4-523f-9244-993da8ba1f35
DOI: 10.1210/jc.85.10.3700

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defect of Villous Cytotrophoblast Differentiation into Syncytiotrophoblast in Down's SyndromeDOI 10.1210/jc.85.10.3700Read

Defect of Villous Cytotrophoblast Differentiation into Syncytiotrophoblast in Down’s Syndrome1Semantic proximity Read

Omics Approaches to Study Formation and Function of Human Placental SyncytiotrophoblastSemantic proximity Read

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistanceSemantic proximity Read

Cell dynamics in human villous trophoblastSemantic proximity Read

Trophoblast Differentiation Affects Crucial Nutritive Functions of Placental Membrane TransportersSemantic proximity Read

Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentasSemantic proximity Read

Trisomy 21- affected placentas highlight prerequisite factors for human trophoblast fusion and differentiationSemantic proximity Read

Human Placental Development Is Impaired by Abnormal Human Chorionic Gonadotropin Signaling in Trisomy 21 PregnanciesSemantic proximity Read

Involvement of the HERV-derived cell-fusion inhibitor, suppressyn, in the fusion defects characteristic of the trisomy 21 placentaSemantic proximity Read

Syncytin-1 modulates placental trophoblast cell proliferation by promoting G1/S transitionSemantic proximity Read

Insulin-like growth factor I and II regulate the life cycle of trophoblast in the developing human placentaSemantic proximity Read

Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placentaSemantic proximity Read