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Article

Defect of Villous Cytotrophoblast Differentiation into Syncytiotrophoblast in Down’s Syndrome1

1 Oct 2000

Abstract excerpt

The syncytiotrophoblast (ST) is one of the major components of the human placenta, as it is involved in feto-maternal exchanges and the secretion of pregnancy-specific hormones. The aim of this study was to elucidate the formation and function of the ST in trisomy 21 (Down's syndrome). We first used the in vitro model of cytotrophoblast differentiation into ST. Cytotrophoblasts were isolated from 15 trisomy...

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PMID: 11061527
DOI: 10.1210/jcem.85.10.6915

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