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Article

Trisomy 21- affected placentas highlight prerequisite factors for human trophoblast fusion and differentiation

29 Oct 2009

Abstract excerpt

Trophoblastic cell fusion is one essential step of the human trophoblast differentiation pathway and is a multifactorial and dynamic process finely regulated and still poorly known. Disturbances of syncytiotrophoblast formation are observed in numerous pathological clinical conditions such as preeclampsia, intrauterine growth retardation and trisomy 21. In this review, we summarize current knowledge of the...

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PMID: 19876835
DOI: 10.1387/ijdb.082766am

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