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Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas

5 Apr 2016

Abstract excerpt

Human embryonic stem cells (ESCs) readily commit to the trophoblast lineage after exposure to bone morphogenetic protein-4 (BMP-4) and two small compounds, an activin A signaling inhibitor and a FGF2 signaling inhibitor (BMP4/A83-01/PD173074; BAP treatment). During differentiation, areas emerge within the colonies with the biochemical and morphological features of syncytiotrophoblast (STB). Relatively pure...

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PMID: 27051068
DOI: 10.1073/pnas.1601630113

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