Article

bulk2scDiff: A Pseudobulk-Conditioned Diffusion Model for Bulk-to-Single-Cell RNASeq Generation

2026-08-20

Abstract excerpt

Bulk RNA sequencing remains the predominant profiling strategy for large clinical cohorts, but it aggregates transcriptional signals across cell populations, thereby masking the underlying cellular heterogeneity. Inferring this heterogeneity from existing bulk transcriptomic data could extend large cohort-based studies that have already been profiled, but constitutes an underdetermined inverse problem, as one bulk...

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Literature Corpus work: a4137941-cfba-5198-b800-df7c62caf6e3
DOI: 10.64898/2026.08.20.745960

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