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High-throughput nanopore sequencing of <i>Treponema pallidum</i> tandem repeat genes <i>arp</i> and <i>tp0470</i> reveals clade-specific patterns and recapitulates global whole genome phylogeny

2022-08-02

Abstract excerpt

Sequencing of most Treponema pallidum ( T. pallidum ) genomes excludes repeat regions in tp0470 and the tp0433 gene, encoding the acidic repeat protein ( arp ). As a first step to understanding the evolution and function of these genes and the proteins they encode, we developed a protocol to nanopore sequence tp0470 and arp genes from 212 clinical samples collected from ten countries on six continents. Both...

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Literature Corpus work
a3f96533-14be-5c33-9699-efbcc79e1bb1
DOI
10.1101/2022.08.02.502389
Open publication

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High-throughput nanopore sequencing of <i>Treponema pallidum</i> tandem repeat genes <i>arp</i> and <i>tp0470</i> reveals clade-specific patterns and recapitulates global whole genome phylogenyDOI 10.1101/2022.08.02.502389
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