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Article

Modulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutations.

PLoS computational biology - 1 Apr 2015

Ganguly Debabani, Chen Jianhan

Abstract excerpt

Intrinsically disordered proteins (IDPs) are frequently associated with human diseases such as cancers, and about one-fourth of disease-associated missense mutations have been mapped into predicted disordered regions. Understanding how these mutations affect the structure-function relationship of IDPs is a formidable task that requires detailed characterization of the disordered conformational ensembles. Implicit...

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Identifiers

PMID: 25897952
DOI: 10.1371/journal.pcbi.1004247
PMCID: PMC4405366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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