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Potential regulation and prognostic model of colorectal cancer with extracellular matrix genes

1 Aug 2024

Abstract excerpt

Background: The tumor microenvironment (TME) of colorectal cancer (CRC) mainly comprises immune cells, stromal cells, tumor cells, as well as the extracellular matrix (ECM), which holds a pivotal position. The ECM affects cancer progression, but its regulatory roles and predictive potential in CRC are not fully understood. Methods: We analyzed transcriptomes from CRC tumors and paired normal tissues to study ECM...

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PMID: 39247375
DOI: 10.1016/j.heliyon.2024.e36164

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