Article

Common postzygotic mutational signature in multiple healthy adult tissues related to embryonic hypoxia

2020-02-17

Abstract excerpt

Postzygotic mutations are acquired in all of the normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenesis causing factors. The process and underlying mechanism of postzygotic mutations in normal tissues is still poorly understood. In this study, we investigated postzygotic mutation spectra in healthy individuals by optimized ultra-deep exome sequencing of time series samples fr...

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Literature Corpus work: a3e035f9-9de8-5579-816a-47f9ac9ec098
DOI: 10.1101/2020.02.17.952473

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