Article

Effects of a novel proteasome inhibitor, UR238 on the tumor immune microenvironment and growth in epithelial ovarian cancer

2025-11-24

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) is a deadly gynecologic malignancy, often diagnosed at an advanced stage and most patients will experience recurrence and resistance to platinum-based chemotherapy. While there are few targeted therapies available for HGSOC, there are no effective immunotherapies available to treat this disease. The ubiquitin-proteasome system (UPS) maintains cellular protein homeostasis by...

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Literature Corpus work: a3ca0ce9-8f6c-542f-8eae-484ecd5b7c2e
DOI: 10.1101/2025.11.21.689729

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