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Emerging therapies targeting the ubiquitin proteasome system in cancer

1 Jan 2014

Abstract excerpt

The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular physiology that tightly regulates cellular protein concentrations with specificity and precision to optimize cellular function. Inhibition of the proteasome has proven very effective in the treatment of multiple myeloma, and this approach is being tested for utility in other malignancies. New pharmaceuticals targeting the...

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PMID: 24382383
DOI: 10.1172/jci71602

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