Article

Aging modifies microstructure and material properties of mineralized cartilage and subchondral bone in the murine knee

2026-04-06

Abstract excerpt

The osteochondral junction is a specialized region ensuring the biomechanical and biological integration of the unmineralized articular cartilage with the subchondral bone through an intermediate layer of mineralized cartilage. This location is of clinical relevance, being the target of osteoarthritis. While aging is considered a risk factor for osteoarthritis, the interplay between microstructural and material ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3b57f47-fedc-5da9-a89e-592a4433cf6e
DOI: 10.64898/2026.04.02.716015

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging modifies microstructure and material properties of mineralized cartilage and subchondral bone in the murine kneeDOI 10.64898/2026.04.02.716015Read

Tissue material properties and computational modelling of the human knee: A critical reviewSemantic proximity Read

Multi-scale analysis of bone chemistry, morphology and mechanics in the oim model of osteogenesis imperfecta.Semantic proximity Read

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature agingSemantic proximity Read

In situ profiling of nanoscale displacements uncovers mechano-architectural predictors of osteoarthritis emergenceSemantic proximity Read

Osteoarthritis Early-, Mid- and Late-Stage Progression in the Rat Medial Meniscus Transection ModelSemantic proximity Read

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging.Semantic proximity Read

Biomaterial Strategies in Osteoarthritis: New Insights Bridging Aging Phenotypes and Hypoxic Microenvironment Pathology.Semantic proximity Read

Characterization of the osteochondral phenotype in human classical osteogenesis imperfecta and in Col1a2oim/oim mice.Semantic proximity Read

Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia.Semantic proximity Read

Modelling Osteoarthritis pathogenesis through Mechanical Loading in an Osteochondral Unit-on-ChipSemantic proximity Read

Fatigue Microdamage as an Essential Element of Bone Mechanics and BiologySemantic proximity Read

Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycleSemantic proximity Read