Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging.

doi:10.1002/jbmr.1495

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Article

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2012

Karunaratne Angelo, Esapa Christopher R, Hiller Jennifer, Boyde Alan, Head Rosie, Bassett J H Duncan, Terrill Nicholas J, Williams Graham R, Brown Matthew A, Croucher Peter I, Brown Steve D M, Cox Roger D, Barber Asa H, Thakker Rajesh V, Gupta Himadri S

Abstract excerpt

Bone diseases such as rickets and osteoporosis cause significant reduction in bone quantity and quality, which leads to mechanical abnormalities. However, the precise ultrastructural mechanism by which altered bone quality affects mechanical properties is not clearly understood. Here we demonstrate the functional link between altered bone quality (reduced mineralization) and abnormal fibrillar-level mechanics...

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PMID: 22161748
DOI: 10.1002/jbmr.1495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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