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Mutation in F-actin Polymerization Factor Suppresses Distal Arthrogryposis Type 5 (DA5) PIEZO2 Pathogenic Variant in <i>Caenorhabditis elegans</i>

2023-07-24

Abstract excerpt

The mechanosensitive PIEZO channel family has been linked to over 26 disorders and diseases. Although progress has been made in understanding these channels at the structural and functional levels, the underlying mechanisms of PIEZO-associated diseases remain elusive. In this study, we engineered four PIEZO-based disease models using CRISPR/Cas9 gene editing. We performed an unbiased chemical mutagen-based genetic...

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Literature Corpus work
692f28f1-7929-5690-85c9-849a59666d4c
DOI
10.1101/2023.07.24.550416
Open publication

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Mutation in F-actin Polymerization Factor Suppresses Distal Arthrogryposis Type 5 (DA5) PIEZO2 Pathogenic Variant in <i>Caenorhabditis elegans</i>DOI 10.1101/2023.07.24.550416
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