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Article

Gemin2 plays an important role in stabilizing the survival of motor neuron complex.

The Journal of biological chemistry - 13 Apr 2007

Ogawa Chihiro, Usui Kengo, Aoki Makoto, Ito Fuyu, Itoh Masayoshi, Kai Chikatoshi, Kanamori-Katayama Mutsumi, Hayashizaki Yoshihide, Suzuki Harukazu

Abstract excerpt

The survival of motor neuron (SMN) protein, responsible for the neurodegenerative disease spinal muscular atrophy (SMA), oligomerizes and forms a stable complex with seven other major components, the Gemin proteins. Besides the SMN protein, Gemin2 is a core protein that is essential for the formation of the SMN complex, although the mechanism by which it drives formation is unclear. We have found a novel...

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Identifiers

PMID: 17308308
DOI: 10.1074/jbc.M609297200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) ComplexSemantic proximity Read ↗

Identification and Characterization of Gemin7, a Novel Component of the Survival of Motor Neuron ComplexSemantic proximity Read ↗

Gemin5, a Novel WD Repeat Protein Component of the SMN Complex That Binds Sm ProteinsSemantic proximity Read ↗

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Emerging Roles of Gemin5: From snRNPs Assembly to Translation ControlSemantic proximity Read ↗

SMN and Gemins: ‘We are family’ … or are we?Semantic proximity Read ↗

Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assemblySemantic proximity Read ↗

Multiprotein Complexes of the Survival of Motor Neuron Protein SMN with Gemins Traffic to Neuronal Processes and Growth Cones of Motor NeuronsSemantic proximity Read ↗

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