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Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System

2025-02-26

Abstract excerpt

<h4>Introduction</h4> The aging lung enters into a state of irreversible cellular growth arrest characterized by senescence. While senescence is beneficial in preventing oncogenic cell proliferation, it becomes detrimental when persistent, promoting chronic inflammation and fibrosis through the senescence-associated secretory phenotype (SASP). Such senescence-related pathophysiological processes play key roles in...

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Literature Corpus work
cf44ddbf-76bf-5a67-9724-47c5106e013c
DOI
10.1101/2025.02.24.639173
Open publication

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Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture SystemDOI 10.1101/2025.02.24.639173
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