Motif-driven microRNA regulation of B cell tolerance uncovers ERα as a female-specific checkpoint

Abstract excerpt

Breakdown of B cell tolerance is a central feature of autoimmune diseases, yet the molecular mechanisms underlying the female predominance of these diseases remain unclear. Here, we identified miR-130b as an essential component of a miRNA network, defined by the GUGCA seed motif, that regulates central B cell tolerance. Elevated miR-130b levels impaired tolerance by promoting the survival of immature B cells upon...

Topics

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• Adenosine and Purinergic Signaling
• Bladder and Urothelial Cancer Treatments
• Chronic Lymphocytic Leukemia Research
• Estrogen and related hormone effects
• Immune Cell Function and Interaction
• Reproductive System and Pregnancy
• Systemic Lupus Erythematosus Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

a30967e2-be7a-5ee3-9361-f322309116b6

DOI

10.1101/2025.01.22.634242