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Article

Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities

12 Apr 2023

Abstract excerpt

Recapitulating the complex structural, mechanical, and electrophysiological properties of native myocardium is crucial to engineering functional cardiac tissues. Here, we report a leaf-venation-directed strategy that enables the compaction and remodeling of cell-hydrogel hybrids into highly aligned and densely packed organizations in predetermined patterns. This strategy contributes to interconnected tubular...

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PMID: 37045852
DOI: 10.1038/s41467-023-37716-1

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