Article

Integrated CHARGE syndrome models reveal epigenetic modulators of reproductive phenotypes

2026-04-02

Abstract excerpt

Loss-of-function variants in CHD7 cause CHARGE syndrome (CS), a rare developmental disorder showing multisystem malformations, including reproductive defects linked to gonadotropin-releasing hormone (GnRH) neuron dysfunction. CHD7 encodes a chromatin remodeler essential for early transcriptional regulation across various tissues. Currently, no pharmacological treatments exist, and approaches aimed at identifying...

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Literature Corpus work: a2dec7fc-287b-5757-9cf9-fbfdf5e1ae0e
DOI: 10.64898/2026.03.31.715488

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