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Article

Early Fracture Healing is Delayed in the Col1a2+/G610C Osteogenesis Imperfecta Murine Model.

Calcified tissue international - 1 Dec 2018

Besio Roberta, Maruelli Silvia, Battaglia Severine, Leoni Laura, Villani Simona, Layrolle Pierre, Rossi Antonio, Trichet Valerie, Forlino Antonella

Abstract excerpt

Osteogenesis imperfecta (OI) is a rare heritable skeletal dysplasia mainly caused by type I collagen abnormalities and characterized by bone fragility and susceptibility to fracture. Over 85% of the patients carry dominant mutations in the genes encoding for the collagen type I α1 and α2 chains. Failure of bone union and/or presence of hyperplastic callus formation after fracture were described in OI patients....

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PMID: 30076439
DOI: 10.1007/s00223-018-0461-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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