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Genetic complementation reveals structure-function links in nodavirus RNA replication complex crowns

2025-12-11

Abstract excerpt

Positive-strand RNA viruses replicate their RNA genomes in virus-induced, membrane-bounded organelles. As first found for nodaviruses, the necked cytosolic portals of these organelles bear ringed “crown” complexes of viral RNA replication proteins that drive synthesis, capping and release of new RNA genomes. Nodavirus crowns contain two 12-mer rings of viral protein A with C-proximal polymerase domains stacked. In...

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Literature Corpus work
a29340e7-0f5d-563e-9fc5-491abdd2744b
DOI
10.64898/2025.12.10.693615
Open publication

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Genetic complementation reveals structure-function links in nodavirus RNA replication complex crownsDOI 10.64898/2025.12.10.693615
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