Article
Sequence of Events in Measles Virus Replication: Role of Phosphoprotein-Nucleocapsid Interactions
10 Jul 2014
Abstract excerpt
UNLABELLED: The genome of nonsegmented negative-strand RNA viruses is tightly embedded within a nucleocapsid made of a nucleoprotein (N) homopolymer. To ensure processive RNA synthesis, the viral polymerase L in complex with its cofactor phosphoprotein (P) binds the nucleocapsid that constitutes the functional template. Measles virus P and N interact through two binding sites. While binding of the P amino...
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