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Article

Non-structural protein-1 is required for West Nile virus replication complex formation and viral RNA synthesis

18 Nov 2013

Abstract excerpt

BACKGROUND: Flavivirus NS1 is a non-structural glycoprotein that is expressed on the cell surface and secreted into the extracellular space, where it acts as an antagonist of complement pathway activation. Despite its transit through the secretory pathway and intracellular localization in the lumen of the endoplasmic reticulum and Golgi vesicles, NS1 is as an essential gene for flavivirus replication. How NS1...

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PMID: 24245822
DOI: 10.1186/1743-422x-10-339

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