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Article

HTRF Kinase Assay Development and Methods in Inhibitor Characterization.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Jia Yong, Manuia Mari, Juarez Jose

Abstract excerpt

Due to their important roles in cellular signaling and their dysfunctions being linked to diseases, kinases have become a class of proteins being actively pursued as potential drug targets. Biochemical assays for kinases have been developed in various formats to facilitate inhibitor screening and selectivity profiling. Here, we focus on one such technology: homogeneous time-resolved fluorescence (HTRF). In this...

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Identifiers

PMID: 26501898
DOI: 10.1007/978-1-4939-3073-9_1

Genes

EGFR

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