Article

Expression of a human cDNA in moss results in spliced mRNAs and fragmentary protein isoforms

2020-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Production of biopharmaceuticals relies on the expression of mammalian cDNAs in host organisms. Here we show that the expression of a human cDNA in the moss Physcomitrella patens generates the expected full-length and four additional transcripts due to unexpected splicing. This mRNA splicing results in non-functional protein isoforms, cellular misallocation of the proteins and low product yield...

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Literature Corpus work: a232cddf-ca4d-5d48-a505-2f8667831bee
DOI: 10.1101/2020.09.30.320721

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