Identification of Two Different 14-α Sterol Demethylase-Related Genes ( <i>cyp51A</i> and <i>cyp51B</i> ) in <i>Aspergillus fumigatus</i> and Other <i>Aspergillus</i> species

Abstract excerpt

Two cyp51-related genes (cyp51A and cyp51B) encoding 14-alpha sterol demethylase-like enzymes were identified in the opportunistic human pathogen Aspergillus fumigatus. PCR amplification using degenerate oligonucleotides based on conserved areas of cytochrome P450 demethylases of other filamentous fungi and yeasts allowed the cloning and sequencing of two different homologue genes in A. fumigatus. Southern...

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