Article

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection <i>in vitro</i> and in a hamster model of COVID-19

2020-12-02

Abstract excerpt

Fast track microfluidic screening of the antibody repertoires of 12 convalescent COVID-19 donors comprising 2.8mio antibodies yielded MTX-COVAB, a human-derived monoclonal antibody with low picomolar neutralization IC50 of SARS-CoV-2. COVAB neutralization potency is on par with the Regeneron cocktail as demonstrated in a comparative neutralization assay. MTX-COVAB shows strong efficacy in vivo and binds to all cu...

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Literature Corpus work: a210dc30-17ef-56f3-bee4-ed61c37768c6
DOI: 10.1101/2020.12.01.406934

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